RMD-QOSM - The Resource Management in Diffserv QoS model

This document describes an NSIS QoS Model for networks that use the Resource Management in Diffserv (RMD) concept. RMD is a technique for adding admission control and preemption function to Differentiated Services (Diffserv) networks. The RMD QoS Model allows devices external to the RMD network to signal reservation requests to edge nodes in the RMD network. The RMD Ingress edge nodes classify the incoming flows into traffic classes and signals resource requests for the corresponding traffic class along the data path to the Egress edge nodes for each flow. Egress nodes reconstitute the original requests and continue forwarding them along the data path towards the final destination. In addition, RMD defines notification functions to indicate overload situations within the domain to the edge nodes

QoS signaling across heterogeneous wired/wireless networks: resource management in diffserv using the NSIS protocol suite

Reservation-based Quality of Service (QoS) in a mixed wireless and wireline environment requires an end-to-end signaling protocol that is capable of adapting to the idiosyncrasies of the different networks. The QoS NSIS Signaling Protocol (QoSNSLP) has been created by the Next Steps In Signaling working group at the IETF to fulfill this need for an adaptive reservation protocol. It allows reservation requests to be interpreted by equipment implementing different QoS models along the path between a data sender and a data receiver. This paper describes the QoS-NSLP, and an example of a particular QoS model that is based on Resource Management in Diffserv (RMD). RMD provides a scalable dynamic resource management method for Diffserv networks. RMD has two basic functions to control the traffic load in a Diffserv domain: it provides admission control for flows entering the network and it has an algorithm that terminates the required amount of flows in case of congestion caused by failures (e.g. link or router) bandwidth and require per-flow reservations. On the other hand, the wireline networks tend to form the backbones and have relatively abundant bandwidth and carry a large number of flows, where aggregation is necessary since per-flow reservations suffer from scalability constraints

Human Cancer Protein-Protein Interaction Network: A Structural Perspective

Protein-protein interaction networks provide a global picture of cellular function and biological processes. Some proteins act as hub proteins, highly connected to others, whereas some others have few interactions. The dysfunction of some interactions causes many diseases, including cancer. Proteins interact through their interfaces. Therefore, studying the interface properties of cancer-related proteins will help explain their role in the interaction networks. Similar or overlapping binding sites should be used repeatedly in single interface hub proteins, making them promiscuous. Alternatively, multi-interface hub proteins make use of several distinct binding sites to bind to different partners. We propose a methodology to integrate protein interfaces into cancer interaction networks (ciSPIN, cancer structural protein interface network). The interactions in the human protein interaction network are replaced by interfaces, coming from either known or predicted complexes. We provide a detailed analysis of cancer related human protein-protein interfaces and the topological properties of the cancer network. The results reveal that cancer-related proteins have smaller, more planar, more charged and less hydrophobic binding sites than non-cancer proteins, which may indicate low affinity and high specificity of the cancer-related interactions. We also classified the genes in ciSPIN according to phenotypes. Within phenotypes, for breast cancer, colorectal cancer and leukemia, interface properties were found to be discriminating from non-cancer interfaces with an accuracy of 71%, 67%, 61%, respectively. In addition, cancer-related proteins tend to interact with their partners through distinct interfaces, corresponding mostly to multi-interface hubs, which comprise 56% of cancer-related proteins, and constituting the nodes with higher essentiality in the network (76%). We illustrate the interface related affinity properties of two cancer-related hub proteins: Erbb3, a multi interface, and Raf1, a single interface hub. The results reveal that affinity of interactions of the multi-interface hub tends to be higher than that of the single-interface hub. These findings might be important in obtaining new targets in cancer as well as finding the details of specific binding regions of putative cancer drug candidates

Protection of Sinorhizobium against Host Cysteine-Rich Antimicrobial Peptides Is Critical for Symbiosis

A bacterial membrane protein, BacA, protects Sinorhizobium meliloti against the antimicrobial activity of host peptides, enabling the peptides to induce bacterial persistence rather than bacterial death

RMD-QOSM - The Resource Management in Diffserv QoS model

This document describes an NSIS QoS Model for networks that use the Resource Management in Diffserv (RMD) concept. RMD is a technique for adding admission control and preemption function to Differentiated Services (Diffserv) networks. The RMD QoS Model allows devices external to the RMD network to signal reservation requests to edge nodes in the RMD network. The RMD Ingress edge nodes classify the incoming flows into traffic classes and signals resource requests for the corresponding traffic class along the data path to the Egress edge nodes for each flow. Egress nodes reconstitute the original requests and continue forwarding them along the data path towards the final destination. In addition, RMD defines notification functions to indicate overload situations within the domain to the edge nodes

Signal-to-noise simulation of n+ on n type Si micro-strip detectors

Using a SPICE network model, we simulated the signal and noise of AC-coupled, single-sided, n+ on n type Si micro-strip detectors connected to PreMux-128 read-out electronics. The detector response was studied before and after neutron irradiation with a fluence of 8.3E13 n/cm2. We compared the simulated and experimental signal-to-noise ratios

Characteristics and SPICE Simulation of a Single-Sided, n+ on n Si Strip Detector Before and After Neutron Irradiation

Capacitance, resistance and current measurements were carried out on single-sided, n+ on n silicon strip detectors. We studied the type inversion after irradiating the detectors with neutron fluences up to 8.3 10 ^13 neutron/cm2. To understand the macroscopic irradiation effects, a SPICE model of the detector was developed. By modelling the set-up of the capacitance measurements, our model was able to reproduce the measured frequency dependence of the relevant capacitances both for non-irradiated and irradiated detectors

NSIS: A New Extensible IP Signaling Protocol Suite

In the last few years a number of applications have emerged that can benefit from networklayer signaling (i.e., the installation, maintenance, and removal of control state in network elements). These applications include path-coupled and path-decoupled quality of service management and resource allocation, as well as network debugging, NAT, and firewall control. These applications call for an extensible and securable signaling protocol. This article discusses some of the recent standardization efforts in the IETF for a new extensible IP signaling protocol suite (NSIS). We describe the design of the NSIS protocol suite, and compare it with RSVP, the current Internet QoS signaling protocol